This is a very broad question and it depends on your business situation & entity type for US- S Corp, C Corp, partnership or sole proprietor.
If you are a C Corporation or S corporation, taxes are very complex so certainly consult a tax professional or CPA.
My response below is for a small business owner. There are so many business deductions available. I will name a few that are most commonly overlooked at the time of tax filing. Also in order to claim these expenses, you need to maintain all the records for documentation purposes :
The entire list is part of an IRS publication which has all the details Pub 334- tax guide for small businesses.
Amending a tax return to claim previously missed deductions can be a costly and time-consuming process, so you should consult a tax professional as it is their specialty. Many CPAs/ tax professionals are so familiar with the tax code, they are able to find all the missed and overlooked deductions saving a lot of $$$ for their clients.
*** Based on our response posted to question on quora
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